Check out your IAT numbers. This could be affecting you greatly like it does with me. Also make sure you are tuning in the same part of day each day, and same kind of weather. SD tuning will take all weather variables into play and screw you up!
If you haven't already, set your bias to 1, and also log up to 2 decimal places for better smoothing, and set a filter for IAT temp range, and TPS.