The higher the compression the better with E85.
Start off with running it as low on fuel as you can, and then fill up with E85.
Monitor the BLM/LTFT, and scale the injector flow value to approx the same % as how much the BLM/LTFT is off.
IF you have a table for Fuel Flow, you are golden. I took my datalog, toss into Excel and then sort by MAP. Taking 0-9, 10-19, 20-29, etc and find the MODE of the LTFT, and use that as your scalar. My LTFT's on my SC 3800 are within 2% max across the board, most of the time 0%. I only scaled it 2x, initially to get it to where I was at 100% E85, and then to fine tune and I haven't NEEDED to mess with it at all.
You can run MAF or SD. I would leave it in MAF personally, but once you get it dialed in on the MAF and you want to fine tune the VE tables, that isn't a bad idea, especially if you are heavily modded, if fairly stock, nothing is really gained.